Reagents and methods useful for detecting diseases of the...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2355870

This invention relates generally to a multimeric polypeptide complex/antigen which may be utilized in detecting or diagnosing diseases of the breat such as breat cancer. Furthermore, the invention relates to methods and kits, for example, which utilize this antigen or an antibody thereto. The complex itself comprises at least one BU101 polypeptide and at least one Mammaglobin polypeptide. In addition, the complex may comprise at least one polypeptide having at least 20 % identity with the amino acid sequence of the BU101 polypeptide, the amino acid sequence of the Mammaglobin polypeptide, and fragments thereof.

La présente invention a trait d'une façon générale à un complexe/antigène polypeptidique multimère qui peut être utilisé pour la détection ou le diagnostic des pathologies du sein comme le cancer du sein. Cette invention concerne, en outre, des méthodes et des kits, par exemple, qui utilisent cet antigène ou un de ses anticorps. Le complexe lui-même comprend au moins un polypeptide BU101, et au moins un polypeptide de mammaglobine. De plus, le complexe peut comprendre au moins un polypeptide présentant au moins 20 % de similitude avec la séquence d'acides aminés du polypeptide BU101, la séquence d'acides aminés du polypeptide de mammaglobine, et ses fragments.

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