C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2287571
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS118 and transcribed from prostate tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS118-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS118 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
L'invention concerne un ensemble de séquences d'ADNc adjacentes et partiellement chevauchantes et de polypeptides codés par ces dernières, appelé PS 118 et transcrit du tissu prostatique. Ces séquences sont utiles pour la détection, le diagnostic, la stadification, la surveillance, le pronostic, la prévention ou le traitement, ou la détermination de la prédisposition d'une personne à des maladies et à des états de la prostate, tel que le cancer de la prostate. L'invention se rapporte aussi à des anticorps qui se fixent spécifiquement à un polypeptide ou à une protéine codé(e) par PS 118, et à des agonistes ou à des inhibiteurs qui empêchent l'action du polypeptide de PS 118 spécifique au tissu, lesdites molécules étant utiles pour le traitement thérapeutique de maladies, de tumeurs ou de métastases de la prostate.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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