C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2358748
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
L'invention se rapporte à un ensemble de séquences d'ADNc contiguës et partiellement chevauchantes ainsi qu'à des peptides codés par ces séquences, lesdites séquences étant dénommées BU101 et transcrites à partir de tissu mammaire. Ces séquences sont utiles pour déceler, diagnostiquer, déterminer le stade, surveiller, prévoir, imager in vivo, prévenir ou traiter, ou déterminer la prédisposition d'un sujet à des pathologies ou troubles mammaires, du type cancer du sein. L'invention concerne également des anticorps qui se lient de manière spécifique à la protéine ou au polypeptide codé par BU101, ainsi que des agonistes et des inhibiteurs qui bloquent l'action du polypeptide BU101 spécifique d'un tissu, lesdites molécules étant utiles au traitement thérapeutique des cancers du sein et des tumeurs ou métastases mammaires.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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