C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C12N 9/64 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2307716
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS247 and transcribed from breast tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS247-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS247 polypeptides, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
L'invention concerne un ensemble séquences d'ADNc, contiguës et se chevauchant partiellement, ainsi que des polypeptides codés par ces séquences, dénommés BS247 et transcrits à partir d'un tissu mammaire. Ces séquences sont utiles pour détecter, diagnostiquer, déterminer les stades d'une maladie évolutive, surveiller, pronostiquer, obtenir une image in vivo, prévenir ou traiter, ou déterminer la prédisposition d'un individu à des maladies et pathologies du sein, comme le cancer du sein. L'invention concerne également des anticorps, lesquels se fixent de manière spécifique sur la protéine ou le polypeptide BS247 codé, ainsi que des agonistes ou inhibiteurs empêchant l'action du polypeptide BS247 spécifique du tissu mammaire, ces molécules étant utiles dans le traitement thérapeutique des maladies, tumeurs ou métastases du sein.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
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