C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/12 (2006.01) C12N 15/12 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2292759
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BL172 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to BL172-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue- specific BL172 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.
L'invention concerne un ensemble de séquences d'ADNc contiguës et partiellement chevauchantes et des polypeptides codés par celles-ci, qui sont appelés BL172 et sont transcrits à partir de tissu des voies urinaires. Ces séquences sont utiles pour détecter, diagnostiquer, stadifier, surveiller, pronostiquer, visualiser in vivo, prévenir ou traiter, ou déterminer la prédisposition d'un sujet à des maladies et à des affections des voies urinaires, tel le cancer des voies urinaires. L'invention concerne également des anticorps qui se fixent spécifiquement au polypeptide ou à la protéine codée par BL172, et des agonistes ou inhibiteurs qui empêchent l'action du polypeptide BL172 spécifique de tissu, ces molécules étant utiles en vue du traitement thérapeutique de maladies, tumeurs ou métastases des voies urinaires.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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