C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2292788
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as LS170 and transcribed from lung tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung, such as lung cancer. Also provided are antibodies which specifically bind to a LS170-encoded polypeptide or protein, and agonists or inhibitors which prevent action of tissue-specific LS170 polypeptides, which molecules are useful for the therapeutic treatment of lung diseases, tumors, or metastases.
Cette invention décrit un groupe de séquences d'ADNc contigües et se chevauchant partiellement ainsi que des polypeptides codés par ces séquences, appelés LS170 et transcrits à partir de tissu pulmonaire. Ces séquences sont utiles dans la détection, le diagnostic, la stadification, la surveillance, le pronostic, l'imagerie in vivo, la prévention ou le traitement de maladies et d'états pathologiques des poumons, tels que le cancer du poumon, ou dans la détermination de la prédisposition d'un individu à ces maladies et états. Cette invention présente également des anticorps qui se lient spécifiquement à un polypeptide ou une protéine codé par LS170, et des agonistes ou inhibiteurs qui empêchent l'action des polypeptides LS170 spécifiques selon les tissus, ces molécules étant utiles dans le traitement thérapeutique des maladies, des tumeurs ou des métastases des poumons.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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