C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/10 (2006.01) C07C 49/213 (2006.01) C07D 403/06 (2006.01) C07F 5/02 (2006.01) G01N 31/22 (2006.01)
Patent
CA 2624598
This invention provides compositions which specifically reacts with peroxynitrite rather than other reactive oxygen species and reactive nitrogen species. This invention also provides related agents for measuring peroxynitrite. This invention also provides related methods for measuring peroxynitrite in a sample, high-throughput screening fluorescent methods for detecting peroxynitrite and high-throughput methods for screening compounds that increase or decrease the production of peroxynitrite comprising using such compositions and agents.
Cette invention concerne des compositions réagissant de manière spécifique avec le peroxynitrite plutôt qu~avec d~autres espèces oxygénées et azotées réactives. Cette invention concerne également des agents associés destinés à mesurer le peroxynitrite. Cette invention concerne également des procédés associés de mesure du peroxynitrite dans un échantillon, des procédés de criblage par fluorescence de haut rendement pour la détection du peroxynitrite et des procédés de haut rendement pour le criblage de composés augmentant ou diminuant la production de peroxynitrite comprenant de tels compositions et agents.
Shen Jiangang
Sun Zhenning
Wang Huali
Yang Dan
Osler Hoskin & Harcourt Llp
The University Of Hong Kong
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