Reagents for inducing an immune response

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/385 (2006.01) A61K 9/127 (2006.01) A61P 31/18 (2006.01) A61P 37/04 (2006.01) G06F 17/50 (2006.01) G06Q 99/00 (2006.01)

Patent

CA 2700892

The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HN-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell.

La présente invention concerne des réactifs (réactifs antigéniques et/ou immunogènes) et des kits qui sont utiles dans une variété de procédés in vitro, in vivo, et ex vivo y compris, par exemple, des procédés pour induire une réponse immunitaire, ou pour générer un anticorps, chez un sujet. Les réactifs décrits ici peuvent être utilisés dans le traitement ou la prévention des infections par le VIH-1. De plus, l'invention concerne des procédés et des compositions utiles pour désigner (ou identifier) un agent qui se lie à une région externe proximale membranaire (MPER) d'un polypeptide gp160 du VIH-1 ou un agent qui inhibe la fusion d'une particule du VIH-1 sur une cellule.

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