Reagents for labeling biomolecules having aldehyde or ketone...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/91 (2006.01) C07D 249/08 (2006.01) C07D 263/60 (2006.01) C07D 265/22 (2006.01) C07D 277/66 (2006.01) C07D 401/04 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2424300

Novel fluorescent derivitization reagents are described that are suitable for coupling to biomolecules that contain aldehyde or ketone functional groups. The method of treating a sample with the derivativization reagents is described. The reagents are particularly useful for labeling glycoproteins or glycopeptides, nucleic acids, and lipopolysaccharides in electrophoresis gels.

L'invention concerne des réactifs fluorescents pour la formation de dérivés, qui sont appropriés au couplage avec des biomolécules renfermant des groupes fonctionnels aldéhyde ou cétone. L'invention concerne également un procédé relatif au traitement d'un échantillon par le biais des réactifs considérés. Les réactifs en question sont particulièrement utiles pour le marquage de glycoprotéines ou de glycopeptides, d'acides nucléiques et de lipopolysaccharides dans les gels d'électrophorèse.

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