Reagents for labeling sh groups, process for the preparation...

Details Reagents for labeling sh groups, process for the preparation... Reagents for labeling sh groups, process for the preparation...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 49/00 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) G01N 33/533 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2221306

Reagents for labeling SH groups which contain acridine compounds of general formula (I) or intermediates thereof; a process for the preparation of the acridine compounds; and a method for labeling analytes with them; wherein A is -(CH2)m1- or -(CH2)m2-Q-(CH2)n- [wherein Q is -S+RX--, -N+RR1X-- (wherein R1 is C1-C6 alkyl or aryl), formula (a) (wherein R2 and R3 are each independently -(CH2)k- (wherein k is 1 to 3)) or -O(CH2CH2O)l- (wherein l is 1 to 3); m1 is 1 to 6; m2 is 0 to 2; and n is 1 to 2]; R is C1-C6 alkyl or aryl; and X is an anion.

L'invention concerne des réactifs pour marquer les groupes SH contenant des composés acridine ayant la formule générale (I) ou leurs intermédiaires; un procédé de préparation de ces composés de l'acridine; un procédé pour les utiliser comme marqueurs d'analytes. Dans la formule (I), A est -(CH¿2?)¿m1?- ou -(CH¿2?)¿m2?-Q-(CH¿2?)¿n?-, [où Q est -S?+¿RX?-¿-, -N?+¿RR¿1?X?-¿- (R¿1? est un C¿1?-C¿6? alkyle ou un aryle), un groupe de la formule (a) (R¿2? et R¿3? sont chacun de manière indépendante -(CH¿2?)¿k?-, avec k compris entre 1 et 3) ou -O(CH¿2?CH¿2?O)¿l?- (l est compris entre 1 et 3); m¿1? est compris entre 1 et 6; m¿2? est compris entre 0 et 2; et n est compris entre 1 et 2]; R est un C¿1?-C¿6? alkyle ou aryle; et X est un anion.

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