C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/281, 260/467
C07C 317/32 (2006.01) C07C 69/732 (2006.01) C07C 317/18 (2006.01) C07D 333/56 (2006.01) C07K 1/06 (2006.01) C07K 2/00 (2006.01) C08F 112/08 (2006.01)
Patent
CA 2018542
Abstract of Disclosure This invention relator to compounds of the formula: Image wherein R is an electron withdrawing group; R1 is H or COZ; X1 and X2 are independently H, lower alkyl, aryl, aryl lower-alkyl; or polystyrene or R and X1 taken together with the carbon atoms to which they are attached form a ring containing from 4 to 15 ring carbon atoms and may contain up to 2 heteroatoms, wherein the heteroatoms are O, S, or N; and Z is an amino acid residue, a peptide residue or a leaving group. The compounds of the present invention are adaptable as blocking or protecting groups for an amine composition useful in peptide synthesis. The present invention is also directed to a method of protecting an amino group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected amino group.
Carpino Louis A.
Philbin Michael
Mcfadden Fincham
Research Corporation Technologies Inc.
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