Reagents for the determination of drugs

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 207/46 (2006.01) C07D 295/155 (2006.01) C07D 401/12 (2006.01) C07D 451/12 (2006.01) C07D 489/02 (2006.01) G01N 33/531 (2006.01) G01N 33/543 (2006.01) G01N 33/544 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2011722

Novel reagents for the detection by immunoassay of drugs in body fluids, their preparation and use are disclosed. The reagents of the present invention correspond to the formula P-[A-D]n where: D is a drug derivative suitably selective for the determination of the presence of the target drug or drug metabolite, A is an activating linker-spacer group having an N-hydroxysuccinimide or isothiocyanate derived linking moiety, P is a poly(amino acid) or polymer capable of covalently bonding with A, and n is less than 1.

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