Real-time detection of nucleic acid reactions

Details Real-time detection of nucleic acid reactions Real-time detection of nucleic acid reactions

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2498713

A process is provided for using oligonucleotide to which a detectable moiety is attached post-synthesis. A metal-containing fluorescent compound affords real-time detection of nucleic acid elongation, amplification, or hybridization. The process is especially advantageous since a detectable moiety is readily attached to an existing oligonucleotide at an internal nucleotide, rather than being limited to attachment at a 3' or 5' terminus.

L'invention concerne un processus pour utiliser un oligonucléotide auquel un groupe fonctionnel est attaché après la synthèse. Un composé fluorescent contenant un métal permet la détection en temps réel de l'élongation, de l'amplification ou de l'hybridation des acides nucléiques. Le processus présente des avantages évidents car un groupe fonctionnel détectable est facilement fixé à un oligonucléotide existant dans un nucléotide interne au lieu d'être limité à une fixation à l'extrémité 3' ou 5'.

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