Receptor activation by gas6

Details Receptor activation by gas6 Receptor activation by gas6

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2214629

An activator of the Rse and Mer receptor protein tyrosine kinases has been identified. The activator is encoded by growth arrest-specific gene 6 (gas6). Accordingly, the invention provides a method of activating the Rse or Mer receptor using gas6 polypeptide. Furthermore, the invention provides a method of enhancing survival, proliferation or differentiation of cells having the Rse or Mer receptor incorporated in their cell membranes which involves exposing those cells to gas6 polypeptide. The types of cells which can be treated according to the method include glial cells such as Schwann cells and mononuclear cells. Kits and articles of manufacture which include gas6 polypeptide are further provided. The invention also relates to gas6 variants.

Un activateur des protéines tyrosines kinases réceptrices Rse et Mer a été identifié. Cet activateur est codé par le gène 6 spécifique de l'arrêt de croissance (Gas6). La présente invention concerne par conséquent un procédé d'activation des récepteurs Rse ou Mer utilisant un polypeptide du Gas6. Cette invention concerne en outre un procédé permettant d'allonger la durée de vie et d'accentuer la prolifération ou la différentiation de cellules comportant le récepteur Rse ou Mer incorporé à leur membrane, ledit procédé consistant à exposer ces cellules au polypeptide du Gas6. Parmi les cellules que l'on peut traiter selon ce procédé, on compte les cellules gliales telles que les cellules de Schwann et des cellules mononucléaires. Par ailleurs, l'invention décrit également des kits et des articles manufacturés qui contiennent le polypeptide du Gas6. Enfin, elle concerne également des variantes du Gas6.

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