C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2612449
The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFR.alpha. antagonist. The invention also provides antibodies that bind to human PDGFR.alpha. and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFR.alpha., and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.
La présente invention concerne des procédés destinés au traitement du cancer osseux, et plus particulièrement du cancer osseux métastatique, par administration d'un antagoniste de récepteur IGF-IR (Insulin-like Growth Factor Receptor) et/ou d'un antagoniste du récepteur PDGFRa (a Platelet Derived Growth Factor Receptor). L'invention concerne également des anticorps qui se lient au PDGFRa humain et neutralisent l'activation du récepteur. L'invention concerne en outre un procédé permettant de neutraliser l'activation d'un PDGFRa, et un procédé permettant de traiter un mammifère atteint d'une affection néoplasique, par utilisation de l'anticorps seul ou associé à d'autres agents.
Fatatis Alessandro
Huber Jim
Loizos Nick
Ludwig Dale L.
Plymate Stephen R.
Drexel University College Of Medicine
Gowling Lafleur Henderson Llp
Imclone Llc
Imclone Systems Incorporated
University Of Washington
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