Receptor derived peptides as modulators of receptor activity

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2322200

Oligopeptides having an amino acid sequence corresponding to a receptor's extracellular domain, and having sequence similarity to regulatory peptides from MHC class I antigens, enhance or replace the physiological response of ligand binding to the corresponding receptor. The oligopeptides are used in diagnosis and therapy of diseases that involve inadequate or inappropriate receptor response as well as in the screening of drug candidates that affect surface expression of receptors. Also useful for drug screening is a modified receptor molecule, where the sequence corresponding to the regulatory peptide is modified or deleted.

La présente invention concerne des oligopeptides dont la séquence d'acides aminés correspond à un domaine extracellulaire de récepteur et qui présentent une analogie de séquence avec des peptides régulateurs d'antigènes MHC de classe I. Ces peptides favorisent ou remplacent la réponse physiologique d'un ligand se liant avec le récepteur correspondant. Ces oligopeptides sont utilisés dans le diagnostic et le traitement de maladies en rapport avec une réponse insuffisante ou inappropriée des récepteurs, ainsi que pour le criblage de médicaments candidats qui ont une incidence sur l'expression de surface des récepteurs. Une molécule réceptrice modifiée, dont la séquence correspondant au peptide régulateur a été modifiée ou supprimée, convient également pour le criblage de médicaments.

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