Receptor derived peptides involved in modulation of response...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/705 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/62 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C07K 14/72 (2006.01) C07K 14/74 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2248255

Oligopeptides having an amino acid sequence corresponding to a receptor's extracellular domain, and having sequence similarity to regulatory peptides from MHC class I antigens, enhance the physiological response of ligand binding to the corresponding receptor. The oligopeptides are used in diagnosis and therapy of diseases that involve inadequate or inappropriate receptor response as well as in the screening of drug candidates that affect surface expression of receptors. Also useful for drug screening is a modified receptor molecule, where the sequence corresponding to the regulatory peptide is modified or deleted.

Des oligopeptides possédant une séquence d'acides aminés correspondant au domaine extracellulaire d'un récepteur et une similarité de séquence avec les peptides régulateurs appartenant aux antigènes de la classe I du CMH améliorent la réponse physiologique de fixation de ligands sur le récepteur correspondant. Ces oligopeptides sont utilisés pour le diagnostic et le traitement de maladies dans lesquelles la réponse des récepteurs est inadéquate ou inappropriée, ainsi que pour le criblage de médicaments candidats susceptibles d'affecter l'expression de surface des récepteurs. Une molécule de récepteur modifiée, dans laquelle la séquence correspondant au peptide régulateur est modifiée ou effacée, est également utile pour le criblage de médicaments.

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