Receptor directed-toxin conjugates

Details Receptor directed-toxin conjugates Receptor directed-toxin conjugates

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2086679

2086679 9200762 PCTABS00010 The invention relates to a targeted toxin molecule comprising a toxin and a proteinaceaous molecule with binding activity for a receptor on the surface of a target cell, whereby the proteinaceous molecule is the ligand on a functional derivative or fragment thereof and the toxin has a molecular weight of no more than 1500 D. More specifically the ligand is IL-2, or preferably only its binding domain. The toxin may be any small toxin, for instance calicheamycin, verrucarin etc.. The toxin molecules according to the invention localize faster and are less immunogenic.

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