Receptor-mediated gene delivery using bacteriophage vectors

Details Receptor-mediated gene delivery using bacteriophage vectors Receptor-mediated gene delivery using bacteriophage vectors

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 47/48 (2006.01) C07K 14/01 (2006.01) C07K 14/50 (2006.01) C12N 7/00 (2006.01) C12N 15/70 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2302293

Filamentous phage particles displaying a ligand on their surface are used to deliver a therapeutic gene to a cell. The ligand is a fusion protein with a phage capsid protein, covalently conjugated to phage particles, or complexed with modified phage particles.

Des virus bactériens filamenteux présentant un ligand sur leur surface sont utilisés pour administrer un gène thérapeutique à une cellule. Le ligand est une protéine de fusion comportant une protéine de capside de phage conjuguée de façon covalente à des virus bactériens, ou formant un complexe avec des virus bactériens modifiés.

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