C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 19/00 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2449412
Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internalized in cells expressing hTfR. The sequences have use for targeting other peptides and proteins into cells expressing hTfR.
L'invention concerne des peptides capables de se lier au récepteur de la transferrine humaine (hTfR) et de s'internaliser avec ledit récepteur. Les séquences HAIYPRH (séq. ID n· 1) et THRPPMWSPVWP (séq. ID n· 2) sont capables de se lier au récepteur de la transferrine humaine et de s'internaliser avec ce dernier. Lorsque ces molécules sont accolées avec d'autres molécules, le produit de la fusion est internalisé dans des cellules exprimant le hTfR. Ces séquences peuvent être utilisées pour le ciblage d'autres peptides et protéines dans des cellules exprimant le hTfR.
Collawan James
Engler Jeffrey
Hwy Lee Jae
Moore Bryan
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Uab Research Foundation
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