Receptor membranes

Details Receptor membranes Receptor membranes

G - Physics

01

N

324/23, 195/35,

G01N 33/545 (2006.01) B01D 69/02 (2006.01) B01D 69/12 (2006.01) B01D 69/14 (2006.01) C07K 17/08 (2006.01) C12N 11/08 (2006.01) C12Q 1/00 (2006.01) G01N 27/333 (2006.01) G01N 33/543 (2006.01) G01N 33/547 (2006.01) G01N 33/563 (2006.01)

Patent

CA 1335879

The present invention provides a membrane comprising a closely packed array of self-assembling amphiphilic molecules, and is characterized in that it incorporates plurality of ion channels, and/for at least a proportion of the self-assembling molecules comprise a receptor molecule conjugated with a supporting entity. The ion channel is selected from the group consisting of peptides capable of forming helices and aggregates thereof, coronands, cryptands, podands and combinations thereof. In the amphiphilic molecules comprising a receptor molecule conjugated with a supporting entity, the receptor molecule has a receptor site and is selected from the group consisting of immunoglobulins, antibodies, antibody fragments, dyes, enzymes and lectins. The supporting entity is selected from the group consisting of a lipid head group, a hydrocarbon chain(s), a cross-linkable molecule and a membrane protein. The supporting entity is attached to the receptor molecule at an end remote from the receptor site. In preferred embodiments the ion channel is gramicidin A, and is preferably gated. Such membranes may be used in the formation of sensing devices..

573217

Affiliated with

Also associated with

Rating

Receptor membranes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Receptor membranes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Receptor membranes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1276803