Receptor membranes and ionophore gating

Details Receptor membranes and ionophore gating Receptor membranes and ionophore gating

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) A61L 27/00 (2006.01) A61L 27/22 (2006.01) A61L 27/28 (2006.01) A61L 27/54 (2006.01) A61L 33/00 (2006.01) A61M 31/00 (2006.01) B01D 69/02 (2006.01) B01D 69/12 (2006.01) B01D 69/14 (2006.01) G01N 27/333 (2006.01) G01N 33/543 (2006.01) G01N 33/544 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2045640

The present invention provides a membrane the conductivity of which is dependent on the presence or absence of an analyte. The membrane comprises a closely packed array of self-assembling amphiphilic molecules and two ionophore components. A receptor molecule reactive with the analyte is provided on one of the ionophore components. The binding of the analyte to the receptor molecule causes a change in the relationship between the ionophore components such that the flow of ion across the membrane is prevented or allowed. The ionophore components are preferably selected from the group consisting of amphotericin B, gramicidin A monomers and combinations thereof, with gramicidin A monomers being particularly preferred. The present invention also provides a membrane including receptors directed against the Fc region of antibodies. These receptors are preferably derived from polyclonal antibodies. These membranes provide a "generic" surface which will bind antibodies in a manner such that the antigen binding regions of the antibody are not hindered. The present invention further provides a device adapted for implantation in a mammalian body, the device being characterised in that it is coated with a membrane comprising a closely packed array of self-assembling amphiphilic molecules and receptor molecules. The receptor molecules being such that the attachment of specific cells to the membrane is enhanced or avoided. It is particularly preferred that the receptor molecules are directed against fibronectin, vitronectin, endothelial cells, or epithelial cells. It is further preferred that the membrane coating the device also includes a plurality of ion channels such as gramicidin.

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