Receptors for tgf-.beta.-related neurotrophic factors

Details Receptors for tgf-.beta.-related neurotrophic factors Receptors for tgf-.beta.-related neurotrophic factors

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) A23J 1/00 (2006.01) A61K 38/24 (2006.01) A61K 38/27 (2006.01) C07K 14/00 (2006.01) C07K 14/71 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) G01N 33/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2291705

A novel growth factor receptor, TrnR2, is disclosed and the human and mouse amino acid sequences are identified. Human and mouse TrnR2 cDNA sequences have been cloned and sequenced. Subcloning the cDNA sequences into vectors and the preparation of cells stably transformed with the vectors are also disclosed. In addition, methods for treating degenerative conditions as well as conditions involving excess levels of GDNF or NTN, and methods for detecting and monitoring TrnR2 levels in patients are provided. Methods for identifying additional members of the TrnR family of growth factor receptors are also provided.

Cette invention se rapporte à un nouveau récepteur des facteurs de croissance, le TrnR2, et à l'identification de séquences d'acides aminés d'origine humaine et murine. On a cloné et séquencé les séquences d'ADNc du TrnR2 d'origine humaine et murine. L'invention se rapporte également au sous-clonage des séquences d'ADNc en vecteurs et à la préparation de cellules ayant subi une transformation stable par ces vecteurs. L'invention se rapporte en outre à des procédés de traitement de troubles dégénératifs et de troubles associés à des niveaux excessifs de GDNF ou de NTN, ainsi qu'à des procédés permettant de déceler la présence de TrnR2 et de surveiller les niveaux de TrnR2 chez des patients. Enfin, l'invention se rapporte à des procédés d'identification d'éléments supplémentaires de la famille TrnR des récepteurs de facteurs de croissance.

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