Recognition molecules interacting specifically with the...

Details Recognition molecules interacting specifically with the... Recognition molecules interacting specifically with the...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 1/22 (2006.01) C07K 16/12 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2258518

The invention relates to a recognition molecule, being capable of interacting with an active site or cleft of a target molecule, which recognition molecule comprises an exposed loop structure, which extends from a basic recognition unit. The loop structure is for example the CDR3 of a camelid species heavy chain antibody having a binding specificity fo the active site or cleft of a target molecule, or a derived version of such a CDR3. The basic recognition unit is for example formed by an antibody-type structure having binding affinity for the target molecule.

L'invention se rapporte à une molécule de reconnaissance capable d'interagir avec le site actif ou la fissure d'une molécule cible, ladite molécule de reconnaissance présentant une structure en boucle formée qui prolonge une unité de reconnaissance de base. La structure en boucle est, par exemple, la région de détermination complémentaire 3 (CDR3) d'un anticorps à chaîne lourde d'une espèce de camélidé ayant une spécificité de liaison au site actif ou à la fissure d'une molécule cible, ou une version dérivée de ladite CDR3. L'unité de reconnaissance de base est, par exemple, constituée par une structure de type anticorps ayant une affinité de liaison pour la molécule cible.

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