C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 35/76 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 15/64 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2501633
The invention relates to novel recombinant adenoviruses which can be obtained from a replicating adenovirus by deleting all or part of the region of the genome of said replicating adenovirus corresponding to that located in the genome of canine adenovirus type 2 (GenBank J04368) between positions 311 and 499, the aforementioned deletion comprising all or part of the region of the genome of the original replicating adenovirus corresponding to that located between positions 311 and 401 in the genome of canine adenovirus type 2. The invention also relates to the uses of said adenoviruses, particularly for therapeutic purposes.
La présente invention est relative à de nouveaux adénovirus recombinants susceptibles d'être obtenus à partir d'un adénovirus réplicatif par délétion de tout ou partie de la région du génome dudit adénovirus réplicatif correspondant à celle située, dans le génome de l'adénovirus canin de type 2 (GenBank J04368), entre les positions 311 et 499, ladite délétion comprenant tout ou partie de la région du génome de l'adénovirus réplicatif d'origine correspondant à celle située entre les positions 311 et 401 dans le génome de l'adénovirus canin de type 2, ainsi qu'à leurs utilisations, notamment à des fins thérapeutiques.
Eloit Marc
Klonjkowski Bernard
Ecole Nationale Veterinaire D'alfort
Institut National de La Recherche Agronomique
Robic
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