Recombinant adenoviral vectors for human tumour gene therapy

Details Recombinant adenoviral vectors for human tumour gene therapy Recombinant adenoviral vectors for human tumour gene therapy

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 35/14 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2248612

A method for treating human tumours by gene therapy is disclosed. In particular, defective recombinant viruses with a sequence coding for a human tumour-specific antigen, and the use thereof for treating or preventing human tumours, as well as producing specific cytotoxic T-cells (CTLs) in vitro or ex vivo, are disclosed. Pharmaceutical compositions comprising said viruses, particularly in injectable form, are also disclosed.

La présente invention concerne une méthode de traitement des tumeurs humaines par la thérapie génique. Elle concerne en particulier des virus recombinants défectifs portant une séquence codant pour un antigène spécifique des tumeurs humaines, et leur utilisation pour le traitement préventif ou curatif des tumeurs humaines ainsi que pour générer in vitro ou ex vivo des CTL spécifiques. Elle concerne également des compositions pharmaceutiques comportant ces virus, notamment sous forme injectable.

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