Recombinant adenovirus

Details Recombinant adenovirus Recombinant adenovirus

C - Chemistry, Metallurgy

07

K

C07K 14/075 (2006.01) C12N 7/00 (2006.01) C12N 15/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2378324

Recombinant adenovirus with changed tropism. In the adenovirus the native pentone fibre, comprising a fibre tail, a fibre shaft and a fibre knob including a trimerisation motif, has been changed in that the native knob containing the cell binding structure and the native trimerisation motif has been removed and a new cellbinding ligand and an external trimerisation motif have been introduced into the virus fiber. Further, the invention relates to the recombinant adenovirus for the treatment of human diseases, either in vivo or by in vitro methods and also to a method for rescuing of recombinant adenovirus fibers into the adenovirus genome.

L'invention concerne un adénovirus recombinant de tropisme modifié. Dans un adénovirus, la fibre pentone native composée d'une queue, d'une tige et d'un spicule incluant un motif de trimérisation, a été changée en ce sens que le spicule natif contenant la structure liaison de cellule et le motif de trimérisation natif ont été enlevés et un nouveau ligand liaison de cellule et un motif de trimérisation externe ont été introduits dans la fibre virus. L'invention concerne également l'adénovirus recombinant destiné au traitement de maladies de l'être humain, in vivo ou par des procédés in vitro, ainsi qu'un procédé de sauvetage de fibres adénovirus recombinant dans le génome adénovirus.

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