C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2342283
The present invention relates to a human type-5 recombinant adenovirus vector for achieving cardiac restricted transcription involving utilization of the cardiomyocyte-restricted cardiac ankyrin repeat protein (CARP) promoter with inclusion of the inverted terminal repeat sequences from human adeno-associated virus (AAV). Using green fluorescent protein (GFP) as a marker gene, the recombinant adenovirus vector (Ad/CG/ITR) is shown to direct transgene expression to myocardial tissue in vivo and in vitro in mouse models.
La présente invention concerne un vecteur d'adénovirus recombinant humain de type 5 pouvant accomplir une transcription cardiaque localisée, qui met en oeuvre le promoteur de la protéine de répétition de l'ankyrine cardiaque (CARP) localisée dans les cardiomyocytes, lequel promoteur est associé aux séquences de répétition terminale inversée issues du virus adéno-associé humain (AAV). L'utilisation de la protéine verte fluorescente (GFP) comme gène marqueur permet de voir que, chez les modèles murins, le vecteur d'adénovirus recombinant (Ad/CG/ITR) dirige l'expression transgénique vers le tissu du myocarde tant in vivo qu'in vitro.
Chien Kenneth R.
Evans Sylvia
Wang Yibin
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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