Recombinant adenoviruses preparation and adenovirus banks

Details Recombinant adenoviruses preparation and adenovirus banks Recombinant adenoviruses preparation and adenovirus banks

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2383225

The invention concerns compositions and methods for preparing recombinant adenoviruses. The resulting adenoviruses can be used for transferring and/or expressing genes in cells, in vitro, ex vivo or in vivo, or also in functional genomics. More particularly, the invention concerns in particular efficient methods for producing adenovirus banks and the use of said banks in functional genomics. The invention also concerns plasmids used for constructing said adenoviruses.

La présente invention concerne des compositions et méthodes pour la préparation d'adénovirus recombinants. Les adénovirus produits peuvent être utilisés pour le transfert et/ou l'expression de gènes dans des cellules, in vitro, ex vivo ou in vivo, ou également en génomique fonctionnelle. En particulier, la présente invention concerne des méthodes particulièrement efficaces pour la production de banques adénovirales et l'utilisation de telles banques en génomique fonctionnelle. Elle concerne également des plasmides utilisés pour la construction de ces adénovirus.

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