Recombinant adenoviruses, use thereof for preparing aavs,...

Details Recombinant adenoviruses, use thereof for preparing aavs,... Recombinant adenoviruses, use thereof for preparing aavs,...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/63 (2006.01) C12N 15/861 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2222270

A recombinant adenovirus in which the expression of a nucleic acid sequence coding for at least one homologous or heterologous gene of viral origin is placed under the control of an inducible promoter, is disclosed. The use of such recombinant adenoviruses for preparing AAVs, and a complementary cell line and preparation method therefor, are also disclosed. Furthermore, pharmaceutical compositions containing such an adenovirus are disclosed.

La présente invention concerne un adénovirus recombinant dans lequel l'expression d'une séquence nucléique codant pour au moins ungène d'origine virale, homologue ou hétérologue, est placée sous contrôle d'un promoteur inductible. Elle se rapporte en outre à l'utilisation de ces adénovirus recombinants pour préparer des AAV, à une lignée cellulaire complémentaire et un procédé de préparation correspondants. Elle vise également des compositions pharmaceutiques contenant un adénovirus selon l'invention.

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