A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2546452
An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
L'invention concerne une composition immunogène, qui comprend une protéine recombinante contenant Bordetella CyaA, ou son fragment, et un peptide correspondant à un antigène tumoral et destiné au traitement d'un cancer. L'invention concerne également des méthodes de traitement utilisant cette composition immunogène. Dans un mode de réalisation, la composition thérapeutique est un traitement contre le mélanome, qui comprend des sites antigéniques issus de l'épitope HLA*0201. Ces sites antigèniques comprennent Tyr ou GnT-V, et sont présents dans les protéines recombinantes CyaA-E5-Tyr et CyaA-E5-GnT-V.
Bauche Cecile
Dadaglio Gilles
Ladant Daniel
Leclerc Claude
Morel Sandra
Centre National de La Recherche Scientifique
Inserm (institut National de La Sante Et de La Recherche Medical
Institut Pasteur
Ludwig Institute For Cancer Research
Robic
LandOfFree
Recombinant adenylate cyclase toxin of bordetella induces t... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant adenylate cyclase toxin of bordetella induces t..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant adenylate cyclase toxin of bordetella induces t... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1845968