Recombinant alphavirus-based vectors with reduced inhibition...

Details Recombinant alphavirus-based vectors with reduced inhibition... Recombinant alphavirus-based vectors with reduced inhibition...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/18 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/40 (2006.01) C12N 15/67 (2006.01) C12N 15/79 (2006.01)

Patent

CA 2304350

Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild- type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.

L'invention concerne des molécules isolées d'acide nucléique comprenant un gène protéine non structural d'alphavirus qui, lorsqu'il est incorporé de manière opérable, dans une particule d'alphavirus recombinante, un système d'initiation à vecteur stratifié eucaryotique ou un réplicon à vecteur ARN, présente un niveau réduit de synthèse à vecteur spécifique ARN, comparativement au type sauvage, et le même niveau, ou un niveau plus élevé de protéines codant pour ARN transcrites par le promoteur de la région de jonction virale, comparativement à une particule d'alphavirus recombinant de type sauvage. L'invention concerne également des réplicons à vecteur ARN, des édifices à vecteur d'alphavirus, ainsi que des systèmes d'initiation à vecteur stratifié eucaryotique contenant les molécules identifiées précitées d'acide nucléique,

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