Recombinant alternaria alternata allergenes

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/35 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/37 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2170355

The invention concerns recombinant DNA molecules which code for polypeptides possessing the antigenicity of the allergens Alta53, Alta22 and Alta11, or for peptides having at least one epitope of these allergens. These molecules are characterized in that they contain nucleic acid sequences which correspond in homologous fashion to the sequences 1, 3-5, 7-9, 12 and 13 or to parts of these sequences, or nucleic acid sequences which hybridize with the above nucleic acid sequences under strictly controlled conditions.

L'invention se rapporte à des molécules d'ADN recombinées qui codent pour des polypeptides qui possèdent l'antigénicité des allergènes Alta53, Alta22 et Alta11 ou pour des peptides présentant au moins un épitope de ces allergènes. Ces molécules sont caractérisées en ce qu'elles présentent des séquences d'acide nucléique qui concordent, de façon homologue, avec les séquences 1, 3-5, 7-9, 12 et 13, ou avec des domaines partiels de ces séquences, ou des séquences d'acide nucléique hybridées avec les séquences d'acide nucléique précitées dans des conditions sévères.

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