Recombinant alveolar surfactant protein

C - Chemistry – Metallurgy – 12 – N

Patent

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195/1.22, 195/1.

C12N 15/12 (2006.01) A61K 35/42 (2006.01) A61K 38/17 (2006.01) A61K 47/24 (2006.01) C07K 14/785 (2006.01)

Patent

CA 1340580

The complete coding sequences and amino acid sequences for both canine and human 32K alveolar surfactant proteins (ASP) ate disclosed; clones for the 10K protein have also been obtained. Methods and vectors for obtaining these proteins in recombinant form are described. The availability of large amounts of these proteins through recombinant techniques permits the use of ASP in suitable pharmaceutical compositions in the treatment of respiratory deficiency syndromes.

497418

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