Recombinant alzheimer's amyloid protein

Details Recombinant alzheimer's amyloid protein Recombinant alzheimer's amyloid protein

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2057053

DNA sequences encoding .beta.-amyloid-related proteins associated with Alzheimer's disease are disclosed. Also provided herein is a DNA sequence encoding a novel protease inhibitor. These sequences are used in producing or constructing recombinant .beta.-amyloid-related proteins and recombinant or synthetic immunogenic peptides. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.

On divulgue des séquences d'ADN codant des protéines apparentées à la bêta-amyloïde, protéine liée à la maladie d'Alzheimer. On divulgue également une séquence d'ADN codant un nouvel inhibiteur de protéase. Ces séquences sont utilisées pour produire ou construire des protéines recombinantes apparentées à la bêta-amyloïde et des peptides immunogènes recombinants ou synthétiques. Des anticorps dirigés contre les protéines recombinantes ou les peptides immunogènes de l'invention peuvent être utilisés pour le diagnostic de la maladie d'Alzheimer dans le liquide cérébral ou par le biais des protéines sériques.

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