Recombinant anti-cd30 antibodies and uses thereof

Details Recombinant anti-cd30 antibodies and uses thereof Recombinant anti-cd30 antibodies and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2430135

The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a cytostatic or cytotoxic effect on Hodgkin's Disease cells. Such proteins include derivatives of monoclonal antibodies AC10 and HeFi-1. The proteins of the invention can be human, humanized, or chimeric antibodies; further, they can be conjugated to cytotoxic agents such as chemotherapeutic drugs. The invention further relates to nucleic acids encoding the proteins of the invention. The invention yet further relates to a method for identifying an anti-CD30 antibody useful for the treatment or prevention of Hodgkin's Disease.

L'invention concerne des méthodes et des compositions destinées au traitement de la maladie de Hodgkin. Les méthodes consistent à administrer des protéines caractérisées en ce qu'elles sont capables de se lier à CD3 ou de faire concurrence à des anticorps monoclonaux AC10 ou HeFi-1 aux fins de liaison à CD30 et d'exercer un effet cytostatique ou cytotoxique sur les cellules de la maladie de Hodgkin. De telles protéines comprennent des dérivés d'anticorps monoclonaux AC10 et HeFi-1. Les protéines selon l'invention peuvent être des anticorps humains, humanisés ou chimères et peuvent être conjuguées avec des agents cytotoxiques, tels que des médicaments de chimiothérapie. L'invention concerne en outre des acides nucléiques codant les protéines selon l'invention. L'invention concerne enfin une méthode d'identification d'un anticorps anti-CD30 utile dans le traitement ou la prévention de la maladie de Hodgkin.

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