Recombinant anti-cd30 antibodies and uses thereof

Details Recombinant anti-cd30 antibodies and uses thereof Recombinant anti-cd30 antibodies and uses thereof

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2527689

The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a cytostatic or cytotoxic effect on Hodgkin's disease cells in the absence of effector cells or complement. Such proteins include derivatives of monoclonal antibodies AC10 and HeFi-1. The proteins of the invention can be human, humanized, or chimeric antibodies; further, they can be conjugated to cytotoxic agents such as chemotherapeutic drugs. The invention further relates to nucleic acids encoding the proteins of the invention. The invention yet further relates to a method for identifying an anti-CD30 antibody useful for the treatment or prevention of Hodgkin's Disease.

La présente invention porte sur des procédés et sur des compositions de traitement de la maladie de Hodgkin, ces procédés consistant à administrer des protéines caractérisées par leur capacité à se lier à CD3 ou à se mesurer aux anticorps monoclonaux AC10 ou HeFi-1 afin de se lier à CD30, et à exercer un effet cytostatique ou cytotoxique sur les cellules atteintes de la maladie de Hodgkin en l'absence des cellules effectrices ou d'un complément. Ces protéines comprennent des dérivés des anticorps monoclonaux AC10 et HeFi-1. Les protéines de l'invention peuvent être des anticorps humains, humanisés ou chimères et peuvent être également conjuguées à des agents cytotoxiques tels que des médicaments chimiothérapeutiques. L'invention porte également sur des acides nucléiques codant les protéines de l'invention, et sur un procédé d'identification d'un anticorps contre CD30 utile dans le traitement ou la prévention de la maladie de Hodgkin.

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