Recombinant anti-interleukin-9 antibodies

Details Recombinant anti-interleukin-9 antibodies Recombinant anti-interleukin-9 antibodies

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2481747

The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL- 9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.

Cette invention concerne des anticorps anti-IL-9 humaine chimériques et humanisés neutralisants ainsi que l'utilisation de ces anticorps d'une part pour identifier des épitopes neutralisants sur l'IL-9 humaine et d'autre part comme médicaments permettant de prévenir et de traiter l'asthme, la réaction bronchique excessive, l'allergie atopique et autres troubles associés. Cette invention porte en particulier sur des anticorps recombinants dérivés de trois anticorps anti-IL-9 humaine de souris nommés infra MH9A3, MH9D1 et MH9L1.

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