Recombinant anti-osteopontin antibody and use thereof

Details Recombinant anti-osteopontin antibody and use thereof Recombinant anti-osteopontin antibody and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07K 14/52 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2461529

A recombinant antibody in which at least the constant regions in the heavy chain and the light chain have been converted into human-origin regions and which inhibits the binding of an integrin recognizing the RGD sequence to osteopontin or its fragment and inhibits the binding of an integrin recognizing the SVVYGLR sequence or a sequence corresponding thereto to osteopontin or its fragment. This antibody is useful as a remedy for autoimmune diseases and a remedy for rheumatism or rheumatoid arthritis. Thus, a method of treating autoimmune diseases, rheumatism or rheumatoid arthritis is provided. This osteopontin antibody is useful in a diagnostic for rheumatism and a method of diagnosing rheumatism too.

L'invention porte sur un anticorps recombinant dont les régions constantes au moins de la chaîne lourde et de la chaîne légère ont été converties en régions d'origine humaine. Cet anticorps inhibe la liaison d'une intégrine reconnaissant la séquence RGD avec l'ostéopontine ou son fragment, et inhibe la liaison d'une intégrine reconnaissant la séquence SVVYGLR ou une séquence correspondant avec l'ostéopontine ou son fragment. Cet anticorps sert de médicament dans le traitement de maladies auto-immunes, du rhumatisme ou de la polyarthrite rhumatoïde. L'invention porte également sur une méthode de traitement de maladies auto-immunes, du rhumatisme ou de la polyarthrite rhumatoïde. L'anticorps contre l'ostéopontine est également indiqué dans le diagnostic du rhumatisme ainsi que dans une méthode de diagnostic du rhumatisme.

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