C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/46 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 9/22 (2006.01) C12N 15/13 (2006.01) C12N 15/55 (2006.01)
Patent
CA 2401916
This invention provides for new recombinant proteins linked to an antibody directed against a cell surface antigen on a cancerous B cell, to form cytotoxic fusion proteins. These proteins are more active than ribonucleases currently available even though the proteins of this invention lack an N-terminal pyroglutamic acid, which has been found to be necessary for ribonucleolytic activity. Because these proteins are recombinant proteins, mutations which increase cytoxicity can be engineered.
Newton Dianne L.
Rybak Susanna M.
Fetherstonhaugh & Co.
The Government Of The United States Of America As Represented By
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