Recombinant anti-tumor rnase

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 38/46 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 9/22 (2006.01) C12N 15/13 (2006.01) C12N 15/55 (2006.01)

Patent

CA 2401916

This invention provides for new recombinant proteins linked to an antibody directed against a cell surface antigen on a cancerous B cell, to form cytotoxic fusion proteins. These proteins are more active than ribonucleases currently available even though the proteins of this invention lack an N-terminal pyroglutamic acid, which has been found to be necessary for ribonucleolytic activity. Because these proteins are recombinant proteins, mutations which increase cytoxicity can be engineered.

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