Recombinant anti-tumor rnase

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/22 (2006.01) A61K 38/46 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01) C12N 15/52 (2006.01) C12N 15/55 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2324646

This invention provides for new recombinant ribonuclease proteins which are active when expressed by bacteria. This allows the recombinant ribonucleases of this invention to be fused in-frame with ligand binding moieties to form cytotoxic fusion proteins. Furthermore, these proteins are more active than ribonucleases currently available even though the proteins of this invention lack an N-terminal pyroglutamic acid, which has been found to be necessary for ribonucleolytic activity. Because these proteins are recombinant proteins, mutations which increase cytotoxicity can be engineered.

Nouvelles protéines ribonucléases recombinées qui sont actives lorsqu'elles sont exprimées par des bactéries. Cela permet aux ribonucléases recombinées selon la présente invention d'être fusionnées dans le cadre avec des ligands pour former des protéines de fusion cytotoxiques. De plus, ces protéines sont plus actives que les ribonucléases actuellement disponibles, même si les protéines selon la présente invention ne possèdent pas d'acide pyroglutamique N-terminal qui s'est révélé être nécessaire pour l'activité de ribonucléase. Ces protéines étant recombinées, il est possible d'obtenir par génie génétique des mutations qui augmentent la cytotoxicité.

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