C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2523449
The invention essentially relates to the production of less immunogenic immunoglobulins by means of genetic engineering and, more specifically, to a monoclonal antibody recognising antigens which contain ganglioside N-glycolyl- GM3 but not other N-glycolyl- or N-acetyl-type gangliosides nor sulphated glycolipids. In particular, the invention relates to peptide sequences encoding a recombinant monoclonal antibody against ganglioside N-glycolyl-GM3 or derivative fragments of same. The invention further relates to pharmaceutical compositions containing the aforementioned antibody or fragments thereof and to the diagnostic or therapeutic use of same for breast cancer and melanoma.
La présente invention concerne essentiellement la production d'immunoglobulines moins immunogènes par génie génétique, et plus spécifiquement à l'aide d'un anticorps monoclonal reconnaissant les antigènes contenant le ganglioside N-glycolyl GM3 mais pas d'autres gangliosides de type N-glycolyl ou N-acétyl, ni les glycolipides sulfatés. La présente invention concerne plus spécifiquement des séquences peptidiques codant pour un anticorps monoclonal de recombinaison contre le ganglioside n-glycolyl GM3, ou des fragments dérivés de celui-ci, ainsi que des compositions pharmaceutiques contenant ledit anticorps ou ses fragments, et leur utilisation diagnostique ou thérapeutique dans le cancer du sein et les mélanomes.
de Acosta Del Rio Cristina Maria Mateo
Frias Ernesto Moreno
Rodriguez Gonzalez Mabel
Rojas Dorantes Gertrudis
Roque Navarro Loudes Tatiana
Centro de Inmunologia Molecular
Macrae & Co.
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