C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/70 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2284665
Methods and compositions relating to recombinant anti-CD22 antibodies with high binding affinity, and immunoconjugates comprising the anti-CD22 antibody linked to a therapeutic agent such as a Pseudomonas exotoxin or a detectable label. The invention provides diagnostic methods, and means to inhibit the growth of malignant B cells.
L'invention concerne des méthodes et compositions se rapportant à des anticorps anti-CD22 de recombinaison présentant une affinité de liaison élevée, et des immunoconjugués comprenant l'anticorps anti-CD22 lié à un agent thérapeutique tel qu'une exotoxine de Pseudomonas ou un marqueur détectable. L'invention concerne des méthodes diagnostiques, et des moyens d'inhibition de la croissance de cellules B malignes.
Fitzgerald David
Kreitman Robert
Mansfield Elizabeth
Pastan Ira
Fetherstonhaugh & Co.
The Government Of The United States Of America As Represented By
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