C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/42 (2006.01) A61P 31/14 (2006.01) C07K 16/10 (2006.01)
Patent
CA 2678628
Disclosed are novel polyclonal antibodies, which target respiratory syncyticilal virus (RSV), as well as novel high affinity antibody molecules reactive with RSV. The polyclonal antibodies may comprise antibody molecules which are reactive with both RSV protein F and RSV protein G, and preferably the polyclonal antibodies target a variety of epitopes on these proteins. The antibody molecules of the invention have shown superior efficacy in vitro and/or in vivo. Also disclosed are methods of producing the antibodies of the invention as well as methods of their use in treatment or prevention of RSV infection.
L'invention concerne de nouveaux anticorps polyclonaux visant le virus respiratoire syncytial (VRS) ainsi que de nouvelles molécules d'anticorps à haute affinité réagissant avec le VRS. Les anticorps polyclonaux peuvent comprendre des molécules d'anticorps qui réagissent avec à la fois la protéine F de VRS et la protéine G de VRS, et de préférence, les anticorps polyclonaux ciblent une variété d'épitopes sur ces protéines. Les molécules d'anticorps de l'invention présentent une efficacité supérieure in vitro et/ou in vivo. L'invention concerne également des procédés de production des anticorps de l'invention ainsi que des procédés pour leur utilisation dans le traitement ou la prévention d'une infection à VRS.
Lantto Johan
Nielsen Henriette Schjoenning
Sim & Mcburney
Symphogen A/s
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