C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61B 10/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/18 (2006.01) C12N 5/20 (2006.01) C12N 15/02 (2006.01) C12N 15/06 (2006.01) C12N 15/09 (2006.01) C12N 15/55 (2006.01) C12N 15/62 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2060544
The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacture of said recombinant antibodies and said monoclonal antibodies, hybridoma cells secreting said monoclonal antibodies, a method of manufacture of said hybridoma cells, DNA coding for the heavy chain variable domain, for the light chain variable domain and for the recombinant antibody, a method of manufacture of said DNA, hybrid vectors suitable for expression of said DNA, host cells transformed with said DNA, and the use of said recombinant antibodies and said monoclonal antibodies in the diagnosis and treatment of tumors.
Groner Bernd
Hardman Norman
Harwerth Ina-Maria
Hynes Nancy E.
Wels Winfried S.
Ag Ciba-Geigy
Fetherstonhaugh & Co.
Novartis Ag
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