A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 16/18 (2006.01) C12N 15/00 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2286305
DNA encoding a recombinant antibody molecule end-specific for an amyloid- .beta. peptide, pharmaceutical compositions thereof, and a method for preventing or inhibiting progression of Alzheimer's Disease by introducing such a DNA molecule into brain cells to express the recombinant antibody molecule and prevent the accumulation of amyloid-.beta. peptides in the cerebrospinal fluid.
L'invention concerne le codage par molécule d'ADN d'une molécule d'anticorps recombiné spécifique contre les terminaisons d'un peptide amyloïde-.beta.. Elle concerne aussi des compositions pharmaceutiques correspondantes et un procédé qui permet d'empêcher ou d'inhiber la progression de la maladie d'Alzheimer en introduisant la molécule d'ADN considérée dans les neurones du cerveau, afin d'exprimer la molécule d'anticorps recombiné et d'éviter l'accumulation de peptides du type amyloïde-.beta. dans le liquide céphalo-rachidien.
Gowling Lafleur Henderson Llp
Intellect Neurosciences Inc.
Mindset Ltd.
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