Recombinant antibody against human insulin-like growth factor

Details Recombinant antibody against human insulin-like growth factor Recombinant antibody against human insulin-like growth factor

C - Chemistry, Metallurgy

07

K

C07K 16/26 (2006.01) A61K 39/395 (2006.01) A61P 3/10 (2006.01) A61P 5/06 (2006.01) A61P 35/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2540138

There have been required drugs for treating diseases in the progress of which IGF participates, for example, cancer, acromegaly and diabetic complications. It is intended to provide a recombinant antibody capable of binding specifically to human IGF-I and human IGF-II and inhibiting the biological activities of human IGF-I and human IGF-II, or a fragment of this antibody; a transformant producing the above antibody or a fragment thereof; a process for producing the above antibody or a fragment thereof; and a drug containing the above antibody or a fragment thereof as the active ingredient.

Il y a un besoin en médicaments destinés au traitement de maladies à l'évolution desquelles participe le facteur de croissance semblable à l'insuline (IGF), par exemple le cancer, l'acromégalie et les complications diabétiques. L'objectif de l'invention est donc d'offrir: un anticorps de recombinaison pouvant se fixer spécifiquement aux facteurs de croissance humains IGF-I et IGF-II et inhiber les activités biologiques desdits facteurs de croissance, ou bien un fragment de cet anticorps; un transformant produisant l'anticorps susmentionné ou un fragment de celui-ci; un procédé de production de l'anticorps susmentionné ou un fragment de celui-ci; et un médicament contenant l'anticorps susmentionné ou un fragment de celui-ci en tant que principe actif.

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