Recombinant antibody fragments as autoantibody antagonists

Details Recombinant antibody fragments as autoantibody antagonists Recombinant antibody fragments as autoantibody antagonists

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2423073

The invention provides methods and compositions for inhibiting autoantibody binding in demyelinating disease such as multiple sclerosis. The compositions comprise immunoglobulin CDR3 sequences derived from combinatorial phage display libraries selected for high-affinity binding to myelin oligodendrocyte glycoprotein.

La présente invention concerne des procédés et des compositions permettant d'inhiber la liaison d'auto-anticorps dans les troubles de démyénilisation comme la sclérose en plaques. Cette composition comprend des séquences CDR3 d'immunoglobuline dérivées des bibliothèques de présentations par phages combinatoires sélectionnées en fonction de leur liaison à haute affinité à la glycoprotéine de l'oligodendrocyte et de la myéline.

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