C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A01N 63/02 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 14/495 (2006.01) C07K 14/55 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/31 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2053911
The present invention describes recombinant antibody toxin fusion proteins which selectively kill cells bearing appropriate antigens or receptors. Construction and expression of a single chain antibody toxin fusion protein, anti-Tac(Pv)-PE40, gene and thereby the production of unproved toxins utilizing PE are described.
L'invention concerne des protéines recombinantes de fusion anticorps-toxine qui tuent de manière sélective des cellules porteuses d'antigènes ou de récepteurs appropriés. L'invention concerne également la construction et l'expression d'une protéine de fusion anticorps-toxine à chaîne unique, appelée anti-Tac (Fv)-PE40, le gène de fusion et la production de toxines améliorées utilisant PE.
Chaudhary Vijay K.
Fitzgerald David
Pastan Ira H.
Queen Cary L.
Waldmann Thomas A.
Borden Ladner Gervais Llp
Protein Design Laboratories Inc.
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
United States Of America Represented By The Secretary Of The Department Of Health And Hum
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