Recombinant antigen for diagnosing rheumatoid arthritis

Details Recombinant antigen for diagnosing rheumatoid arthritis Recombinant antigen for diagnosing rheumatoid arthritis

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2208072

A method is described for diagnosing rheumatoid arthritis by providing a recombinant antigen (RAMA) and detecting rheumatoid arthritis-associated IgM antibodies against the RAMA antigen in patient sera. The RAMA antigen comprises SEQ ID NO:3 and peptides substantially homologous thereto. A purified and isolated DNA encoding the RAMA antigen and a transformed host containing the DNA are also disclosed.

Description d'une méthode pour le diagnostic de la polyarthrite rhumatoïde au moyen d'un antigène recombinant (antigène RAMA) et pour la détection dans le sérum du patient d'anticorps IgM associés à l'arthrite rhumatoïde dirigés contre l'antigène RAMA. L'antigène RAMA comprend ID SEQ NO 3 et des peptides sensiblement homologues. Un ADN purifié et isolé codant pour l'antigène RAMA et un hôte transformé contenant l'ADN sont également décrits.

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